Is there continued evidence for an association between abacavir usage and myocardial infarction risk in individuals with HIV? A cohort collaboration
Identifieur interne : 001C18 ( Main/Exploration ); précédent : 001C17; suivant : 001C19Is there continued evidence for an association between abacavir usage and myocardial infarction risk in individuals with HIV? A cohort collaboration
Auteurs : Caroline A. Sabin [Royaume-Uni] ; Peter Reiss [Pays-Bas] ; Lene Ryom [Danemark] ; Andrew N. Phillips [Royaume-Uni] ; Rainer Weber [Suisse] ; Matthew Law [Australie] ; Eric Fontas [France] ; Amanda Mocroft [Royaume-Uni] ; Stephane De Wit [Belgique] ; Colette Smith [Royaume-Uni] ; Francois Dabis [France] ; Antonella D Rminio Monforte [Italie] ; Wafaa El-Sadr [États-Unis] ; Jens D. Lundgren [Danemark]Source :
- BMC Medicine [ 1741-7015 ] ; 2016.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Agents antiVIH (usage thérapeutique), Australie, Didéoxynucléosides (usage thérapeutique), Europe, Facteurs de risque, Femelle, Gestion de la pharmacothérapie (), Gestion de la pharmacothérapie (tendances), Humains, Infarctus du myocarde (épidémiologie), Infections à VIH (traitement médicamenteux), Infections à VIH (épidémiologie), Modèles logistiques, Mâle, Odds ratio, Pharmacovigilance, Types de pratiques des médecins (tendances), États-Unis d'Amérique, Évaluation des risques ().
- MESH :
- tendances : Gestion de la pharmacothérapie, Types de pratiques des médecins.
- traitement médicamenteux : Infections à VIH.
- usage thérapeutique : Agents antiVIH, Didéoxynucléosides.
- épidémiologie : Infarctus du myocarde, Infections à VIH.
- Adulte, Adulte d'âge moyen, Australie, Europe, Facteurs de risque, Femelle, Gestion de la pharmacothérapie, Humains, Modèles logistiques, Mâle, Odds ratio, Pharmacovigilance, États-Unis d'Amérique, Évaluation des risques.
English descriptors
- KwdEn :
- Adult, Anti-HIV Agents (therapeutic use), Australia, Dideoxynucleosides (therapeutic use), Europe, Female, HIV Infections (drug therapy), HIV Infections (epidemiology), Humans, Logistic Models, Male, Medication Therapy Management (statistics & numerical data), Medication Therapy Management (trends), Middle Aged, Myocardial Infarction (epidemiology), Odds Ratio, Pharmacovigilance, Practice Patterns, Physicians' (trends), Risk Assessment (methods), Risk Factors, United States.
- MESH :
- chemical , therapeutic use : Anti-HIV Agents, Dideoxynucleosides.
- drug therapy : HIV Infections.
- epidemiology : HIV Infections, Myocardial Infarction.
- methods : Risk Assessment.
- statistics & numerical data : Medication Therapy Management.
- trends : Medication Therapy Management, Practice Patterns, Physicians'.
- Adult, Australia, Europe, Female, Humans, Logistic Models, Male, Middle Aged, Odds Ratio, Pharmacovigilance, Risk Factors, United States.
Abstract
In March 2008, the D:A:D study published results demonstrating an increased risk of myocardial infarction (MI) for patients on abacavir (ABC). We describe changes to the use of ABC since this date, and investigate changes to the association between ABC and MI with subsequent follow-up.
A total of 49,717 D:A:D participants were followed from study entry until the first of an MI, death, 1 February 2013 or 6 months after last visit. Associations between a person’s 10-year cardiovascular disease (CVD) risk and the likelihood of initiating or discontinuing ABC were assessed using multivariable logistic/Poisson regression. Poisson regression was used to assess the association between current ABC use and MI risk, adjusting for potential confounders, and a test of interaction was performed to assess whether the association had changed in the post-March 2008 period.
Use of ABC increased from 10 % of the cohort in 2000 to 20 % in 2008, before stabilising at 18–19 %. Increases in use pre-March 2008, and subsequent decreases, were greatest in those at moderate and high CVD risk. Post-March 2008, those on ABC at moderate/high CVD risk were more likely to discontinue ABC than those at low/unknown CVD risk, regardless of viral load (≤1,000 copies/ml: relative rate 1.49 [95 % confidence interval 1.34–1.65]; >1,000 copies/ml: 1.23 [1.02–1.48]); no such associations were seen pre-March 2008. There was some evidence that antiretroviral therapy (ART)-naïve persons at moderate/high CVD risk post-March 2008 were less likely to initiate ABC than those at low/unknown CVD risk (odds ratio 0.74 [0.48–1.13]). By 1 February 2013, 941 MI events had occurred in 367,559 person-years. Current ABC use was associated with a 98 % increase in MI rate (RR 1.98 [1.72–2.29]) with no difference in the pre- (1.97 [1.68–2.33]) or post- (1.97 [1.43–2.72]) March 2008 periods (interaction
Despite a reduction in the channelling of ABC for patients at higher CVD risk since 2008, we continue to observe an association between ABC use and MI risk. Whilst confounding cannot be fully ruled out, this further diminishes channelling bias as an explanation for our findings.
Url:
DOI: 10.1186/s12916-016-0588-4
PubMed: 27036962
PubMed Central: 4815070
Affiliations:
- Australie, Belgique, Danemark, France, Italie, Pays-Bas, Royaume-Uni, Suisse, États-Unis
- Angleterre, Aquitaine, Grand Londres, Hollande-Septentrionale, Hovedstaden, Lombardie, Nouvelle-Aquitaine, Nouvelle-Galles du Sud, Provence-Alpes-Côte d'Azur, Région de Bruxelles-Capitale, État de New York
- Amsterdam, Bordeaux, Bruxelles, Copenhague, Londres, Milan, Nice, Sydney
- University College de Londres, Université Bordeaux II, Université d'Amsterdam
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Le document en format XML
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A cohort collaboration</title><author><name sortKey="Sabin, Caroline A" sort="Sabin, Caroline A" uniqKey="Sabin C" first="Caroline A." last="Sabin">Caroline A. Sabin</name><affiliation wicri:level="4"><nlm:aff id="Aff1">Research Department of Infection and Population Health, University College London (UCL), Royal Free Campus, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Research Department of Infection and Population Health, University College London (UCL), Royal Free Campus, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Reiss, Peter" sort="Reiss, Peter" uniqKey="Reiss P" first="Peter" last="Reiss">Peter Reiss</name><affiliation wicri:level="4"><nlm:aff id="Aff2">Academic Medical Center, Division of Infectious Diseases and Department of Global Health, University of Amsterdam, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Academic Medical Center, Division of Infectious Diseases and Department of Global Health, University of Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region><settlement type="city">Amsterdam</settlement></placeName><orgName type="university">Université d'Amsterdam</orgName></affiliation></author><author><name sortKey="Ryom, Lene" sort="Ryom, Lene" uniqKey="Ryom L" first="Lene" last="Ryom">Lene Ryom</name><affiliation wicri:level="3"><nlm:aff id="Aff3">Denmark Centre for Health and Infectious Disease Research (CHIP), Department of Infectious Diseases, Section 2100, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Denmark Centre for Health and Infectious Disease Research (CHIP), Department of Infectious Diseases, Section 2100, Rigshospitalet, University of Copenhagen, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Phillips, Andrew N" sort="Phillips, Andrew N" uniqKey="Phillips A" first="Andrew N." last="Phillips">Andrew N. Phillips</name><affiliation wicri:level="4"><nlm:aff id="Aff1">Research Department of Infection and Population Health, University College London (UCL), Royal Free Campus, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Research Department of Infection and Population Health, University College London (UCL), Royal Free Campus, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Weber, Rainer" sort="Weber, Rainer" uniqKey="Weber R" first="Rainer" last="Weber">Rainer Weber</name><affiliation wicri:level="1"><nlm:aff id="Aff4">Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich</wicri:regionArea><wicri:noRegion>Zurich</wicri:noRegion></affiliation></author><author><name sortKey="Law, Matthew" sort="Law, Matthew" uniqKey="Law M" first="Matthew" last="Law">Matthew Law</name><affiliation wicri:level="3"><nlm:aff id="Aff5">The Kirby Institute, University of New South Wales (UNSW), Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>The Kirby Institute, University of New South Wales (UNSW), Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Fontas, Eric" sort="Fontas, Eric" uniqKey="Fontas E" first="Eric" last="Fontas">Eric Fontas</name><affiliation wicri:level="3"><nlm:aff id="Aff6">Department of Public Health, Nice University Hospital, Nice, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Public Health, Nice University Hospital, Nice</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Nice</settlement></placeName></affiliation></author><author><name sortKey="Mocroft, Amanda" sort="Mocroft, Amanda" uniqKey="Mocroft A" first="Amanda" last="Mocroft">Amanda Mocroft</name><affiliation wicri:level="4"><nlm:aff id="Aff1">Research Department of Infection and Population Health, University College London (UCL), Royal Free Campus, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Research Department of Infection and Population Health, University College London (UCL), Royal Free Campus, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="De Wit, Stephane" sort="De Wit, Stephane" uniqKey="De Wit S" first="Stephane" last="De Wit">Stephane De Wit</name><affiliation wicri:level="3"><nlm:aff id="Aff7">Le Centre Hospitalier Universitaire (CHU) Saint-Pierre, Department of Infectious Diseases, Brussels, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Le Centre Hospitalier Universitaire (CHU) Saint-Pierre, Department of Infectious Diseases, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Smith, Colette" sort="Smith, Colette" uniqKey="Smith C" first="Colette" last="Smith">Colette Smith</name><affiliation wicri:level="4"><nlm:aff id="Aff1">Research Department of Infection and Population Health, University College London (UCL), Royal Free Campus, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Research Department of Infection and Population Health, University College London (UCL), Royal Free Campus, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Dabis, Francois" sort="Dabis, Francois" uniqKey="Dabis F" first="Francois" last="Dabis">Francois Dabis</name><affiliation wicri:level="4"><nlm:aff id="Aff8">Université Bordeaux Segalen, INSERM U897, Epidemiologie-Biostatistique, CHU de Bordeaux, Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Bordeaux Segalen, INSERM U897, Epidemiologie-Biostatistique, CHU de Bordeaux, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement><settlement type="city">Bordeaux</settlement></placeName><orgName type="university">Université Bordeaux II</orgName></affiliation></author><author><name sortKey="D Rminio Monforte, Antonella" sort="D Rminio Monforte, Antonella" uniqKey="D Rminio Monforte A" first="Antonella" last="D Rminio Monforte">Antonella D Rminio Monforte</name><affiliation wicri:level="3"><nlm:aff id="Aff9">Dipartimento di Scienze della Salute, Clinica di Malattie Infectitive e Tropicali, Azienda Ospedaliera-Polo Universitario San Paolo, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Scienze della Salute, Clinica di Malattie Infectitive e Tropicali, Azienda Ospedaliera-Polo Universitario San Paolo, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="El Sadr, Wafaa" sort="El Sadr, Wafaa" uniqKey="El Sadr W" first="Wafaa" last="El-Sadr">Wafaa El-Sadr</name><affiliation wicri:level="2"><nlm:aff id="Aff10">ICAP-Columbia University and Harlem Hospital, New York, NY USA</nlm:aff><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>ICAP-Columbia University and Harlem Hospital, New York</wicri:cityArea></affiliation></author><author><name sortKey="Lundgren, Jens D" sort="Lundgren, Jens D" uniqKey="Lundgren J" first="Jens D." last="Lundgren">Jens D. Lundgren</name><affiliation wicri:level="3"><nlm:aff id="Aff3">Denmark Centre for Health and Infectious Disease Research (CHIP), Department of Infectious Diseases, Section 2100, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Denmark Centre for Health and Infectious Disease Research (CHIP), Department of Infectious Diseases, Section 2100, Rigshospitalet, University of Copenhagen, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author></analytic><series><title level="j">BMC Medicine</title><idno type="eISSN">1741-7015</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Anti-HIV Agents (therapeutic use)</term><term>Australia</term><term>Dideoxynucleosides (therapeutic use)</term><term>Europe</term><term>Female</term><term>HIV Infections (drug therapy)</term><term>HIV Infections (epidemiology)</term><term>Humans</term><term>Logistic Models</term><term>Male</term><term>Medication Therapy Management (statistics & numerical data)</term><term>Medication Therapy Management (trends)</term><term>Middle Aged</term><term>Myocardial Infarction (epidemiology)</term><term>Odds Ratio</term><term>Pharmacovigilance</term><term>Practice Patterns, Physicians' (trends)</term><term>Risk Assessment (methods)</term><term>Risk Factors</term><term>United States</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Agents antiVIH (usage thérapeutique)</term><term>Australie</term><term>Didéoxynucléosides (usage thérapeutique)</term><term>Europe</term><term>Facteurs de risque</term><term>Femelle</term><term>Gestion de la pharmacothérapie ()</term><term>Gestion de la pharmacothérapie (tendances)</term><term>Humains</term><term>Infarctus du myocarde (épidémiologie)</term><term>Infections à VIH (traitement médicamenteux)</term><term>Infections à VIH (épidémiologie)</term><term>Modèles logistiques</term><term>Mâle</term><term>Odds ratio</term><term>Pharmacovigilance</term><term>Types de pratiques des médecins (tendances)</term><term>États-Unis d'Amérique</term><term>Évaluation des risques ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-HIV Agents</term><term>Dideoxynucleosides</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>HIV Infections</term><term>Myocardial Infarction</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Risk Assessment</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Medication Therapy Management</term></keywords><keywords scheme="MESH" qualifier="tendances" xml:lang="fr"><term>Gestion de la pharmacothérapie</term><term>Types de pratiques des médecins</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à VIH</term></keywords><keywords scheme="MESH" qualifier="trends" xml:lang="en"><term>Medication Therapy Management</term><term>Practice Patterns, Physicians'</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Agents antiVIH</term><term>Didéoxynucléosides</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Infarctus du myocarde</term><term>Infections à VIH</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Australia</term><term>Europe</term><term>Female</term><term>Humans</term><term>Logistic Models</term><term>Male</term><term>Middle Aged</term><term>Odds Ratio</term><term>Pharmacovigilance</term><term>Risk Factors</term><term>United States</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Australie</term><term>Europe</term><term>Facteurs de risque</term><term>Femelle</term><term>Gestion de la pharmacothérapie</term><term>Humains</term><term>Modèles logistiques</term><term>Mâle</term><term>Odds ratio</term><term>Pharmacovigilance</term><term>États-Unis d'Amérique</term><term>Évaluation des risques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>In March 2008, the D:A:D study published results demonstrating an increased risk of myocardial infarction (MI) for patients on abacavir (ABC). We describe changes to the use of ABC since this date, and investigate changes to the association between ABC and MI with subsequent follow-up.</p></sec><sec><title>Methods</title><p>A total of 49,717 D:A:D participants were followed from study entry until the first of an MI, death, 1 February 2013 or 6 months after last visit. Associations between a person’s 10-year cardiovascular disease (CVD) risk and the likelihood of initiating or discontinuing ABC were assessed using multivariable logistic/Poisson regression. Poisson regression was used to assess the association between current ABC use and MI risk, adjusting for potential confounders, and a test of interaction was performed to assess whether the association had changed in the post-March 2008 period.</p></sec><sec><title>Results</title><p>Use of ABC increased from 10 % of the cohort in 2000 to 20 % in 2008, before stabilising at 18–19 %. Increases in use pre-March 2008, and subsequent decreases, were greatest in those at moderate and high CVD risk. Post-March 2008, those on ABC at moderate/high CVD risk were more likely to discontinue ABC than those at low/unknown CVD risk, regardless of viral load (≤1,000 copies/ml: relative rate 1.49 [95 % confidence interval 1.34–1.65]; >1,000 copies/ml: 1.23 [1.02–1.48]); no such associations were seen pre-March 2008. There was some evidence that antiretroviral therapy (ART)-naïve persons at moderate/high CVD risk post-March 2008 were less likely to initiate ABC than those at low/unknown CVD risk (odds ratio 0.74 [0.48–1.13]). By 1 February 2013, 941 MI events had occurred in 367,559 person-years. Current ABC use was associated with a 98 % increase in MI rate (RR 1.98 [1.72–2.29]) with no difference in the pre- (1.97 [1.68–2.33]) or post- (1.97 [1.43–2.72]) March 2008 periods (interaction <italic>P =</italic> 0.74).</p></sec><sec><title>Conclusions</title><p>Despite a reduction in the channelling of ABC for patients at higher CVD risk since 2008, we continue to observe an association between ABC use and MI risk. 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sortKey="Meraviglia, P" uniqKey="Meraviglia P">P Meraviglia</name></author><author><name sortKey="Schiavini, M" uniqKey="Schiavini M">M Schiavini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chini, M" uniqKey="Chini M">M Chini</name></author><author><name sortKey="Tsoupras, Ab" uniqKey="Tsoupras A">AB Tsoupras</name></author><author><name sortKey="Mangafas, N" uniqKey="Mangafas N">N Mangafas</name></author><author><name sortKey="Tsogas, N" uniqKey="Tsogas N">N Tsogas</name></author><author><name sortKey="Papakonstantinou, Vd" uniqKey="Papakonstantinou V">VD Papakonstantinou</name></author><author><name sortKey="Fragopoulou, E" uniqKey="Fragopoulou E">E Fragopoulou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haugaard, Ak" uniqKey="Haugaard A">AK Haugaard</name></author><author><name sortKey="Lund, Tt" uniqKey="Lund T">TT Lund</name></author><author><name sortKey="Birch, C" uniqKey="Birch C">C Birch</name></author><author><name sortKey="Fonsholt, F" uniqKey="Fonsholt F">F Fonsholt</name></author><author><name sortKey="Troseid, M" uniqKey="Troseid M">M Troseid</name></author><author><name sortKey="Ullum, H" uniqKey="Ullum H">H Ullum</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Danaei, G" uniqKey="Danaei G">G Danaei</name></author><author><name sortKey="Tavakkoli, M" uniqKey="Tavakkoli M">M Tavakkoli</name></author><author><name sortKey="Hernan, Ma" uniqKey="Hernan M">MA Hernán</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>Belgique</li><li>Danemark</li><li>France</li><li>Italie</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Suisse</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Aquitaine</li><li>Grand Londres</li><li>Hollande-Septentrionale</li><li>Hovedstaden</li><li>Lombardie</li><li>Nouvelle-Aquitaine</li><li>Nouvelle-Galles du Sud</li><li>Provence-Alpes-Côte d'Azur</li><li>Région de Bruxelles-Capitale</li><li>État de New York</li></region><settlement><li>Amsterdam</li><li>Bordeaux</li><li>Bruxelles</li><li>Copenhague</li><li>Londres</li><li>Milan</li><li>Nice</li><li>Sydney</li></settlement><orgName><li>University College de Londres</li><li>Université Bordeaux II</li><li>Université d'Amsterdam</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Sabin, Caroline A" sort="Sabin, Caroline A" uniqKey="Sabin C" first="Caroline A." last="Sabin">Caroline A. Sabin</name></region><name sortKey="Mocroft, Amanda" sort="Mocroft, Amanda" uniqKey="Mocroft A" first="Amanda" last="Mocroft">Amanda Mocroft</name><name sortKey="Phillips, Andrew N" sort="Phillips, Andrew N" uniqKey="Phillips A" first="Andrew N." last="Phillips">Andrew N. Phillips</name><name sortKey="Smith, Colette" sort="Smith, Colette" uniqKey="Smith C" first="Colette" last="Smith">Colette Smith</name></country><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Reiss, Peter" sort="Reiss, Peter" uniqKey="Reiss P" first="Peter" last="Reiss">Peter Reiss</name></region></country><country name="Danemark"><region name="Hovedstaden"><name sortKey="Ryom, Lene" sort="Ryom, Lene" uniqKey="Ryom L" first="Lene" last="Ryom">Lene Ryom</name></region><name sortKey="Lundgren, Jens D" sort="Lundgren, Jens D" uniqKey="Lundgren J" first="Jens D." last="Lundgren">Jens D. Lundgren</name></country><country name="Suisse"><noRegion><name sortKey="Weber, Rainer" sort="Weber, Rainer" uniqKey="Weber R" first="Rainer" last="Weber">Rainer Weber</name></noRegion></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Law, Matthew" sort="Law, Matthew" uniqKey="Law M" first="Matthew" last="Law">Matthew Law</name></region></country><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Fontas, Eric" sort="Fontas, Eric" uniqKey="Fontas E" first="Eric" last="Fontas">Eric Fontas</name></region><name sortKey="Dabis, Francois" sort="Dabis, Francois" uniqKey="Dabis F" first="Francois" last="Dabis">Francois Dabis</name></country><country name="Belgique"><region name="Région de Bruxelles-Capitale"><name sortKey="De Wit, Stephane" sort="De Wit, Stephane" uniqKey="De Wit S" first="Stephane" last="De Wit">Stephane De Wit</name></region></country><country name="Italie"><region name="Lombardie"><name sortKey="D Rminio Monforte, Antonella" sort="D Rminio Monforte, Antonella" uniqKey="D Rminio Monforte A" first="Antonella" last="D Rminio Monforte">Antonella D Rminio Monforte</name></region></country><country name="États-Unis"><region name="État de New York"><name sortKey="El Sadr, Wafaa" sort="El Sadr, Wafaa" uniqKey="El Sadr W" first="Wafaa" last="El-Sadr">Wafaa El-Sadr</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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